OUT has been involved in advocacy since 2006. Past efforts include same-sex marriage, victim empowerment and hate crimes, and the Sexual Offenses Act.

Current advocacy work focuses on HIV and hate crime work. OUT has played a major role in securing a LGBT Sector within the South African National AIDS Council (SANAC). OUT represents issues within the SANAC High Plenary, Programme Implementation Committee, the Women's Sector and the Research and Monitoring Task Team.

OUT has also played an active role in proposing a national programme to reach the MSM related targets in the current National Strategic Plan and to ensure inclusion of targets in the NSP for 2012 and beyond. OUT participates in the Hate Crime Working Group and its efforts to include hate crimes within legislation and to acknowledge sexual orientation as a basis of vulnerability.

OUT participated in the activities of the now-defunct Joint Working Group and its efforts to promote the interest of LGBT community groups in South Africa.

OUT is a member of the African Men for Sexual Health and Rights (AMSHeR) and plays an active role to promote the interest of MSM in the continent. AMSHER is also very active in addressing HIV issues including programming in this area.

OUT further engages on an ongoing basis with the Department of Justice and Constitutional Development Task Team addressing hate crimes against LGBTI people, and other related structures.